--- title: Harvard Closer to Zone Diet Alignment After 20 Years description: A Harvard Medical School study indicates it is the combination of foods, not simply their calorie content, that determines long-term weight loss and gain. image: https://blog.zoneliving.com/hubfs/Imported_Blog_Media/zone_blog_harvardzone-1-1.jpg --- ##### Shop By Category - [ Best Seller ](https://zoneliving.myshopify.com/collections/best-sellers) - [ Omega-3s ](https://zoneliving.myshopify.com/collections/omega-3-fish-oil) - [ Polyphenols ](https://zoneliving.myshopify.com/collections/polyphenols) - [ Zone Foods ](https://zoneliving.myshopify.com/collections/zone-foods) - [ Blood Tests ](https://zoneliving.myshopify.com/collections/blood-tests) - [ Supplements ](https://zoneliving.myshopify.com/collections/supplements) - [ Books ](https://zoneliving.myshopify.com/collections/books) - [ Skin Care ](https://zoneliving.com/collections/skin-care-1) - [ Metabolic Engineering ](https://zoneliving.com/collections/metabolic-engineering) - Best Seller [ Shop All ](https://zoneliving.myshopify.com/collections/all) ##### Shop By Zone Food - [ Zone Muffins ](https://zoneliving.com/collections/zone-muffins) - [ Zone Pasta ](https://zoneliving.myshopify.com/collections/zone-pasta) - [ Zone Shakes ](https://zoneliving.myshopify.com/collections/zone-shakes) - [ Zone Bars ](https://zoneliving.myshopify.com/collections/zone-nutrition-bars) - [ Olive Oil ](https://zoneliving.myshopify.com/collections/olive-oil) [ Shop All ](https://zoneliving.myshopify.com/collections/all) [![easy-to-make](https://blog.zoneliving.com/hubfs/Global_2023/easy-to-make.webp) ](https://zoneliving.myshopify.com/blogs/recipes) Easy-to-make recipes just for you. 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D | Creator of the Zone Diet # [Harvard Closer to Zone Diet Alignment After 20 Years](https://blog.zoneliving.com/drsears/blog/harvard-moving-closer-to-zone-diet) - ** - [**](https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fblog.zoneliving.com%2Fdrsears%2Fblog%2Fharvard-moving-closer-to-zone-diet) - [**](https://www.twitter.com/share?url=https%3A%2F%2Fblog.zoneliving.com%2Fdrsears%2Fblog%2Fharvard-moving-closer-to-zone-diet) - [**](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.zoneliving.com/drsears/blog/harvard-moving-closer-to-zone-diet) - [**](https://plus.google.com/share?url=https%3A%2F%2Fblog.zoneliving.com%2Fdrsears%2Fblog%2Fharvard-moving-closer-to-zone-diet) Written by Dr. Barry Sears on April 27, 2015 The recent article by Smith et al in the 2015 issue of the American Journal of Clinical Nutrition tried to answer the question of primary prevention of weight gain (1). This is actually a germane question since most diet studies focus on overweight/obese individuals losing weight after years of gaining weight.  Thus this new article endeavors to determine primary prevention strategies against developing heart disease, as opposed to secondary prevention strategies to try to prevent another heart attack. The road to obesity is not a rapid one.  Weight gain in adults is usually 1 lb./year (0.45 kg/year).  Simple-minded thinking would suggest just reducing calorie intake would be the answer.  After all, you should only need to reduce your calorie intake by less than 10 calories per day to theoretically prevent the gain of 1 pound of fat per year.  However, a previous study by Harvard Medical School has indicated it is the combination of foods, not simply their calorie content that determines long-term weight gain (2). So after a lot of statistical hand-waving, the article concludes that to prevent weight gain, one should embark on a dietary program to consume more low-fat protein and low-glycemic-load carbohydrates (i.e., non-starchy vegetables and fruits like berries).  A final recommendation is to avoid eating low-fat meals since doing so tends to make a person overcompensate by eating more carbohydrates. As one of authors of the study stated, *"Our study adds to growing new research that counting calories is not the most effective strategy for long-term weight management and prevention.  Some foods help prevent weight gain, other make it worse."* I think I stated the same thing 20 years with the publication of my first book, [*The Zone*](http://www.zonediet.com/shop/more-products/books/the-zone/).  However, unlike Harvard, I provided the science to support why such a dietary strategy works.  It is ultimately about controlling the hormonal responses induced by the combination of the foods you eat at every meal that determines whether or not you gain weight or lose excess weight.  If you want to prevent weight gain, you have to follow a dietary program that maintains diet-induced hormones in a zone consistent with insulin balance.  If you want to lose excess weight, you have to follow a dietary program that gets diet-induced hormones into that same zone to maintain insulin balance because it is excess insulin that makes you fat and keeps you fat.  And if you want to prevent lost weight from coming back, you have to follow a dietary program that gets diet-induced hormones into that same zone to maintain insulin balance so that you don't regain the lost weight. Perhaps these Harvard researchers may have overlooked *The Zone*, even though it was a #1 *New York Times* bestseller and one of the best-selling diet books of all time.  Furthermore, I provided precise instructions in *The Zone* on the macronutrient balance of such a diet needed to control hormonal responses (3).  Although it is a bell-shaped curve, the center point is at 40% low-glycemic-load carbohydrates, 30% low-fat protein and 30% fat as shown below: ![Zone Diet Protein-to-Glycemic Load Chart](https://blog.zoneliving.com/hs-fs/hubfs/Imported_Blog_Media/zonediet-balance-of-protein-1.png?width=480&height=360&name=zonediet-balance-of-protein-1.png) Ignorance of my dietary concepts by Harvard is probably not the case either, since one of the authors of the most recent study did clinical experiments in 1999 to demonstrate that a single Zone meal of equal calories could dramatically alter hormonal responses compared to higher-carbohydrate-containing meals (4). Sometimes a picture is worth a thousand words, so here is the summation of hormonal changes that these Harvard investigators observed with a single meal. ![Chart displaying the Zone Diet's effect on hormonal responses](https://blog.zoneliving.com/hs-fs/hubfs/Imported_Blog_Media/zonediet-hormonal-responses-1.png?width=480&height=360&name=zonediet-hormonal-responses-1.png) While I am the first to admit that science moves slowly, it is nice to see that Harvard is finally beginning to admit that maybe a "calorie is not a calorie," and that the hormonal consequences of each meal should be considered if we want to prevent weight gain and the co-morbid chronic disease conditions (diabetes, heart disease, and cancer) that come with increasing weight gain.  Maybe some day in the future, they will also mention that the reason that weight gain is associated with these chronic diseases is because of increased inflammation.  I think I also wrote about that subject more than a decade ago (5).  Maybe they might mention my book the next time.[![New call-to-action](https://no-cache.hubspot.com/cta/default/4011822/daffa570-1055-4766-af51-e09d66a17e47.png)](https://cta-redirect.hubspot.com/cta/redirect/4011822/daffa570-1055-4766-af51-e09d66a17e47) **References:** 1. Smith JD, Hou T, Ludwig DS, Rimm EB, Willett WC, Hu FB, and Mozaffarian D. "Changes in intake of protein foods, carbohydrate amount and quality and long-term weight change." Amer J Clin Nutr 101:doi 10:3945/ajcn (2015). 2. Mozaffarian D, Hao T, Rimm EB, Willett WC, and Hu FB. "Changes in diet and lifestyle and long-term weight gain in women and men."  N Engl J Med 364:2392-2404 (2011). 3. Sears B. *The Zone*.  Regan Books.  New York, NY (1995). 4. [Ludwig DS](http://www.ncbi.nlm.nih.gov/pubmed/?term=Ludwig%20DS%5BAuthor%5D&cauthor=true&cauthor_uid=10049982), [Majzoub JA](http://www.ncbi.nlm.nih.gov/pubmed/?term=Majzoub%20JA%5BAuthor%5D&cauthor=true&cauthor_uid=10049982), [Al-Zahrani A](http://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Zahrani%20A%5BAuthor%5D&cauthor=true&cauthor_uid=10049982), [Dallal GE](http://www.ncbi.nlm.nih.gov/pubmed/?term=Dallal%20GE%5BAuthor%5D&cauthor=true&cauthor_uid=10049982), [Blanco I](http://www.ncbi.nlm.nih.gov/pubmed/?term=Blanco%20I%5BAuthor%5D&cauthor=true&cauthor_uid=10049982), and [Roberts SB](http://www.ncbi.nlm.nih.gov/pubmed/?term=Roberts%20SB%5BAuthor%5D&cauthor=true&cauthor_uid=10049982). "High-glycemic-index foods, overeating, and obesity." [Pediatrics](http://www.ncbi.nlm.nih.gov/pubmed/10049982) 103:E26 (1999). 5. Sears B. *The Anti-Inflammation Zone*.  Regan Books.  New York, NY (2005). 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