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Dr. Sears' Blog

Breaking down the latest research on Anti-Inflammatory Nutrition
Written By: Dr. Barry Sears, Ph. D | Creator of the Zone Diet

Written by Dr. Barry Sears
on July 20, 2021

Now that the Covid-19 epidemic seems to be slowing down, we must contend with the other epidemic that shows no signs of abating. That is our obesity epidemic. If you have excess body fat, you are already inflamed. That excess adipose tissue is the staging area for ongoing inflammatory attacks on every organ in the body. It is also the first sign that your metabolism is becoming dysfunctional, thus reducing your ability to burn excess stored fat for energy.

Metabolism is defined as those complex processes that take place in your body to keep you alive. Metabolism allows you to breathe, digest food, circulate blood, keep the brain working, fight infections, and so on. All these processes require massive amounts of ATP. The “traffic cop” that controls your ability to convert stored body fat into ATP is called AMPK.

AMPK can be considered the “master switch” of metabolism. If AMPK is optimized, you can burn stored body fat faster to make greater amounts of ATP. Conversely, if AMPK is inhibited, you accumulate incoming calories as excess body fat.

Losing excess body fat is a challenge but keeping the excess body fat from returning is even more difficult because your metabolism slows down after losing any bodyweight. The good news is that AMPK activity is under robust dietary control. The best way to optimize AMPK activity is following the Zone Pro-Resolution Nutrition program. By following the anti-inflammatory Zone diet, you can constantly activate your AMPK while reducing calorie intake without hunger or fatigue. Adding omega-3 fatty acids and polyphenols as dietary supplements will also increase AMPK activity through different pathways. Although any one of these three nutritional interventions is good, when you combine all three, they are synergistic, as I describe in my latest book, The Resolution Zone.

On the other hand, AMPK activity is inhibited by consuming either excess dietary calories or excess glucose. If you inhibit AMPK, then incoming calories easily get converted and stored at excess body fat.

Activating AMPK is the biological key that allows you to burn fat faster and prevent its return. It’s also totally under your dietary control. Once you master these basic dietary concepts of the Zone Pro-Resolution Nutrition program, burning fat faster becomes a lifetime reality that leads to a longer and better life. Additional benefits from activating AMPK will be slowing down your rate of aging and improving the efficiency of your immune system. This is the real reason why you want to be in the Zone.


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